New Drug Aims to Counter ‘Ozempic Butt’ Muscle Loss Linked to Obesity Treatments
New drug to stop Ozempic butt – A groundbreaking drug named apitegromab may help patients undergoing obesity treatments like Wegovy and Mounjaro retain muscle mass, potentially preventing the so-called ‘Ozempic butt’ effect, as revealed by a study published in the Nature Medicine journal.
Study Reveals Muscle Loss in Obesity Jabs
Research indicates that about one-third of weight loss from GLP-1 medications is attributed to muscle rather than fat. In a trial involving 102 adults, predominantly women, those who combined apitegromab with their obesity drugs maintained significantly more lean mass while still achieving fat reduction, according to body scans.
“The findings are promising but should be considered as encouraging early evidence rather than definitive proof of clinical benefit,” noted Dr. Marie Spreckley, a Cambridge University expert not involved in the study.
Experts emphasize that further research is necessary before recommending apitegromab widely. While GLP-1 drugs suppress appetite and enhance satiety, leading to rapid weight loss, they can cause excessive muscle and tissue breakdown. This side effect has prompted some users to describe their changing body shape as saggy or deflated, a trend observed by US plastic surgeons.
How the Drug Works and Its Broader Applications
Apitegromab functions by inhibiting a protein responsible for muscle degradation. It is currently administered via intravenous infusion in clinical trials and is being studied for other conditions, such as spinal muscular atrophy. The manufacturer is exploring options for self-injection using a specialized pen, similar to the convenience of GLP-1 jabs.
Dr. Brendan Gabriel, a nutrition and health specialist at the University of Aberdeen, suggested that the drug might benefit individuals experiencing rapid muscle loss but may not be suitable for all users of GLP-1 medications. He stressed that muscle preservation could enhance strength and overall health outcomes, though more extensive trials are required.
Practical Tips for Maintaining Muscle Mass
While medication is a factor, lifestyle adjustments are equally vital. Strength training, even without gym access, can be achieved through everyday activities that challenge muscles beyond normal effort. The NHS recommends starting with small, manageable sessions and gradually increasing frequency to at least two times per week.
Diet also plays a crucial role. Consuming 20–40 grams of protein per meal has been shown to support muscle retention. A simple guideline is to fill a quarter of each plate with protein-rich foods like meat, fish, legumes, or tofu. Snacks such as Greek yogurt, hard-boiled eggs, and almonds can further aid this process.
